AICAR Peptide: Research Uses
15 January 2024
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Studies suggest that when compared to adenosine monophosphate, AICAR is somewhat similar. Research studies have suggested its efficacy in preventing myocardial ischemia after a heart attack. Because of its antioxidant characteristics, AICAR may be useful in delaying the onset of physiological aging. The potential of AICAR as a mediator of the consequences of inflammatory disorders, diabetes, and autoimmune illnesses is an area of active investigation.

AICAR Peptide: What is it?

AICAR, an abbreviation for 5-aminoimidazole-4-carboxamide ribonucleoside, is a small peptide that has been hypothesized to function in energy balance and various metabolic processes. AICAR is theorized to control insulin receptors and insulin-related cellular processes in muscle cells. The cancer-fighting and heart/cardiovascular tissue-protecting potential of AICAR are now the subject of intensive inquiry. AMP kinase (AMPK) activators include AICAR.

Research suggests AICAR may manage acute lymphoblastic leukemia, the activated version of naturally occurring acadesine. Acadesine, similar to AICAR, may have anti-cancer characteristics, as suggested by research. Additionally, findings imply it may help avoid the early phases of blood clotting by suppressing platelet activity.

AICAR Peptide and Insulin Resistance

Investigations purport that AICAR may decrease inflammation in adipose tissue. Reducing inflammation improves glucose homeostasis and insulin sensitivity even in the absence of weight changes because inflammation in fat is linked to elevated insulin resistance. It seems that AICAR may influence inflammation in adipose tissue via many routes, one of which involves SIRT1 and macrophages.

AICAR has also been hypothesized to affect adipose inflammation. AMPK may reduce inflammatory reactions in metabolic diseases in both normal and diabetic mice. Insulin sensitivity, energy balance, lipid metabolism, and inflammatory markers were all speculated to improve in mouse studies when AICAR activated AMPK.

The amount of GLUT-4 insulin receptors on muscle cell surfaces increases during physical activity. Research suggests it may decrease glucose levels and insulin resistance and might be among the best ways to increase glucose absorption by muscle cells.

AICAR Peptide and Cancer

AMPK is involved in various cancer-related processes, including tumor growth regulation and metastasis. Overall, studies show that the enzyme’s prolonged activation slows cancer cell metabolism and makes cancer cells more vulnerable to environmental insults, ultimately leading to cancer cell death. This has been shown in rat studies as well as in cell cultures. Researchers are examining whether AICAR may increase the efficacy of other chemotherapy substances when combined.

As suggested by studies on thyroid cancer cells, AICAR could potentially function by inducing apoptosis, commonly known as programmed cell death. Inducing p21 accumulation and caspase 3 activation seems to mediate this action. Inhibition of cancer cell multiplication and survival is the overall perceived impact.

AICAR Peptide and Inflammation

There is data to suggest that AMPK activators are involved in cellular inflammation. One of the reasons a diabetic compound works is because it decreases inflammation and increases pancreatic function, according to studies. In inflammatory diseases such as hepatitis, atherosclerosis, colitis, acute lung injury, and asthma, AICAR has been hypothesized to have preventive function.

The potential of AICAR as a mediator of inflammatory disorders and autoimmune illnesses is a topic of active investigation. For example, ACIAR has suggested promise in lowering inflammation in colitis in mouse experiments. By decreasing NF-kappaB activation in macrophages and TH1- and TH17-type cytokines, AICAR is a key inhibitor of immunological responses in this context.

AICAR Peptide and the Heart

Inflammation is associated with a lot of cardiac diseases. Atherosclerosis and other vascular diseases might be slowed down if inflammation could be controlled. Studies on rabbits with atherosclerosis suggest that AICAR may inhibit the growth of vascular smooth muscle. This is a key feature of cardiovascular disease and a contributing factor to the gradual failure of cardiac stents. Without medications that raise the risk of bleeding, reducing vascular inflammation might lessen the likelihood of immediate and delayed stent insertion problems.

Additionally, studies have purported that activation of AMPK may decrease immunological responses, contributing to atherosclerosis. Macrophage proliferation occurs when LDL levels build. A heart attack may develop from the buildup of plaques. The prevalence of heart disease and heart attacks may be reduced if anything could be done to slow this increase.

AICAR Peptide and Fertility

The potential of the peptide AICAR to enhance sperm motility, energy metabolism, and fertilization capacity has been the focus of most AICAR research. Animal studies in cats, goats, and chickens have hinted that AMPK activators such as AICAR may enhance sperm motility by regulating energy consumption. AICAR’s regulation of spermatozoa’s energetic enzyme activity has been hypothesized to affect the overall fertilization capacity.

Biotech Peptides sells AICAR and other peptides made in the USA for research and education, not for human consumption. Licensed researchers are the only ones who should purchase AICAR.